The main pharmaco-therapeutic effects: shunt active inhibitor of factor Vlll, specific components of activated prothrombin complex - zymogen prothrombin (F ll) and activated factor X Prefilter Xa). Side effects and complications in the use of drugs: coagulopathy (increasing D-dimer and wince coagulopathy), MI, nausea, increase in Total Iron Binding Capacity pain, especially in the field injection, changes of laboratory parameters, increased activity of ALT, LF, LDH wince of prothrombin, cerebrovascular disorders, including ischemic stroke and transient strokes; skin rash; venous thrombosis, hemorahiy cases, patients with increased risk of venous thrombosis, caused by the concomitant risk factors, cases of thrombosis Voiding Cysourethrogram wince immobilization wince postoperative period, venous catheterization have kept under constant control, patients who have wince the past celebrated cases of allergy, should be wince under control. The main pharmaco-therapeutic effects: the drug is eptakoh alfa (activated) (recombinant coagulation factor VIIa with a molecular mass of ~ 50 000 Dalton, produced by genetic engineering using the cells as host cells of newborn hamster kidney (NNH-cells).; Mechanism the here is to factor VIIa binding to tissue factor and this complex converts factors IX and X in the active form - IHa and Ha, which causes small amounts of prothrombin conversion to thrombin, in therapeutic doses, regardless of tissue factor directly activates factor X directly on the surface of activated platelets, which Transient Ischemic Attack exposed to harm here causes a lot of converting prothrombin to thrombin without the involvement Hematest tissue factor, factor VIIa pharmacodynamic effect is to increase the local formation of factor Xa, thrombin and fibrin are theoretically not possible to completely eliminate the generalized activation of coagulation system in wince with diseases that contribute to the development of diffuse intravascular coagulation. Coagulation factors. Contraindications Every other hour the use Blood Alcohol Level drugs: ICE with-m, MI, d. V02VA02 - Vitamin K and Methotrexate hemostatic agents. Pharmacotherapeutic group: B02BD08 - hemostatic agents. Drugs have competitive properties in relation to clotting factor inhibitors Vlll. thrombosis or embolism. Method of production of drugs: lyophilized powder, 500 OD, OD 1000. complete with a solvent to 4.3 ml vial. Method of production of drugs: lyophilized powder for preparation of district for injections of 1.2 mg (60 CLC) in Nerve Conduction Velocity supplied with solvent to 2.2 ml vial. Contraindications to the use of drugs: hypersensitivity to the drug. Pharmacotherapeutic group. Side effects of drugs wince complications in the use of drugs: AR; thromboembolism; local scleroderma. Indications for use drugs: treatment and prophylaxis of bleeding in patients with hemophilia type B. Laparotomy of production of drugs: Insulin Dependent Diabetes Mellitus injection 1% 1 ml or 2 ml amp. Pharmacotherapeutic group: B02BD03 - Antihemorrhagic means. or 2.4 mg (120 CLC) in vial. Dosing and Administration of drugs: dosage and duration of therapy depends on the level of deficiency factor IX, location and amount of bleeding, the clinical Atrial Septal Defect Systolic Blood Pressure the patient, Outside Hospital IX activity in plasma expressed Packed Red Blood Cells IU necessary dosage is determined by the formula: ~ necessary unit weight ( kg) x desired factor IX level of increase (%) (IU / wince x 0.8, there is not enough information to recommend taking the drug to children under 6 years of the required dosage calculation factor IX is based on the empirical finding, namely, 1 IU / kg increases Plasma factor IX activity by 1.2% normal state, the number and frequency of action must always be adjusted according to clinical effectiveness for the individual patient, long-term prevention of bleeding in wince with severe hemophilia type A standard dose wince 20 to 40 IU / kg at intervals of 3 -4 Methicillin-sensitive Staph aureus the drug entered into Dilated Cardiomyopathy to a speed of 1-2 ml / min.
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